CBD interacts with the body through the endogenous cannabinoid system (ECS) or endocannabinoid system. First discovered in the late 1980’s, the endocannabinoid system regulates the body’s homeostasis, or general state of balance, impacting such functions as mood, sleep, appetite, hormone regulation, and pain and immune response. Like an acrobat on a highwire, as the environment around us impacts our normal balance, the endocannabinoid system “corrects” by mediating our body’s reaction to keep us level.
Today, dozens of companies produce CBD in an array of forms. CBD can be inhaled through vape pens, applied in topical salves, ingested in edibles, or swallowed in oil-based tinctures. Oil has become the dominant CBD delivery method for kids with epilepsy, since it is easy to administer and ingest, and there is no shortage of it available for sale online. There are dozens of companies boasting names like Healthy Hemp Oil, Dose of Nature, and Natural Organic Solutions, each of them selling CBD products at prices ranging from trivial to dizzyingly steep. You don’t have to look hard to find them. If you have a PayPal account and $100 to spare, you could have a vial of hemp oil delivered to your doorstep.
For every pound of Rebel Blend coffee sold or brewed at Coffee By Design coffeehouses during the year, $1 is donated to the Rebel Blend Fund. Every year CBD accepts proposals from Maine artists and/or small arts organizations whose projects may fall between the funding cracks. A committee made up of CBD staff members selects several grants. The Rebel Blend committee looks for thought-provoking projects that have the potential to engage people across the state in meaningful conversation.
Dr. Tim Shu, founder and CEO of VETCBD, says that the interaction of cannabidiol with the endocannabinoid system in dogs can provide relief from a wide variety of physiological and neurological conditions, by ‘modulating the chemical components’ responsible for nausea, stress, anxiety, pain, and even gastrointestinal conditions brought on by infection.
The vast majority of CBD oils come in bottles measuring either 15 milliliters (mL), or 0.5 ounces; or 30 mL, or 1 ounce. However, CBD concentration is more important than bottle size. Concentration refers to the ratio of hemp oil solution (measured in mL) compared to the amount of CBD cannabinoid (measured in milligrams, or mg). A 15-mL bottle may contain 100 mg of CBD, 300 mg, 500 mg, or more. The higher the mg amount, the stronger the CBD oil will be. For this reason, the ‘mg’ measurement is also referred to as the oil’s strength; i.e., 400-mg oil might be called 400-strength oil.
The good news is that most of the official research done on CBD oil has shown that there are very few negative side effects from using it. However, CBD is not without some side effects. Most notably, in the clinical studies for epilepsy, sedation was one of the more common side effects. Decreased appetite and diarrhea were also seen in some patients. Depending on what other medicines they are taking, certain patients may need to have periodic blood tests to check on liver function.

Chronic pain: The body’s ECS plays a role in alleviating and managing pain, so CBD oil can work as a supplement for individuals with medical conditions that cause chronic pain, such as arthritis and multiple sclerosis. CBD oil also increases levels of adenosine in the brain; adenosine is a neurotransmitter that aids cardiovascular function and eases painful inflammation.
Ian Ford, owner of Caffeine Underground, prepared my order as if it were any other latte (CBD-infused drip, mochas, and cappuccinos are also available), except he included a healthy amount of the CBD-infused coffee with the regular blend. Once I got my drink, I sat down at one of the tables. It was just before noon on a weekday, and the coffee shop was mostly empty, except for a few people working on laptops.

FDA DISCLOSURE Representations regarding the efficacy and safety of Rosebud CBD have not been evaluated by the Food and Drug Administration. The FDA only evaluates foods and drugs, not supplements like these products. These products are not intended to diagnose, prevent, treat, or cure any disease. Click here (https://www.ncbi.nlm.nih.gov/pubmed/22625422) and here (https://www.ncbi.nlm.nih.gov/pubmed/18728714) to find evidence of a test, analysis, research, or study describing the benefits, performance or efficacy of CBD Oil based on the expertise of relevant professionals. These statements have not been evaluated by the FDA and are not intended to diagnose, treat, or cure any disease. Always check with your physician before starting a new dietary supplement program. The Cannabidiol (CBD) in Rosebud CBD is a natural constituent of industrial hemp plant and grown in the United States of America. Rosebud CBD does not sell or distribute any products that are in violation of the United States Controlled Substances Act (US CSA). All products contain less than 0.3% THC. All products are legal in all 50 states.
I used a “cbd tincture 250mg”. After about 3 weeks I started passing blood and protein in urine. I stopped and it cleared up. A couple weeks later I decided to try again and within 3 days it happened again. Could this be due to the type of oil I used or might I have the same problem with any oil I try? It was helping my hip pain and crohns. Thanks!
The safety and risks of using CBD for dogs have not yet been researched. The U.S. Food and Drug Administration has not approved CBD and has not issued a dosing chart. Therefore, we do not know what size dosage would be toxic. Any medication or supplement carries the risk of a reaction. It is always advisable, when giving your dog something new, to start out with small amounts and then closely monitor the effects. And always check with your veterinarian first.
A study analysis in Journal of Pain Research confirms that topical use of certain cannabinoid topicals can reduce pain in animals with inflammation or neuropathic pain. And science has found topical creams with THC and CBD help relieve pain for conditions like multiple sclerosis. But for the vast majority of chronic pain—and most certainly for acute pain like post-workout—the scientific jury is 100 percent still out. "There's a little bit of data in support of CBD for pain relief, but to go from animal to human is a giant leap," Sexton says.
We do sell pure, isolated cannabidiol in crystalline form. This CBD isolate is somewhere between 96% and 99.9% pure. While all the Certificates of Analysis (COAs) for our CBD Isolate reveal cannabidiol levels at 90%-100%, we are almost completely certain that every batch of our CBD Isolate extract has been more than 99% pure. The deviation in results is due to instances of unreliable third-party testing.

Dispensaries: In states where marijuana is legal for recreational use, dispensaries are a common sight. They are much rarer in states with more restrictions. In states that permit the use of medical marijuana, hemp-based CBD oils do not normally require a prescription but marijuana-based oils do. Like brick-and-mortar locations, dispensaries offer more customer service. However, as noted, this may not be an option depending on the buyer’s state of residence. Also, CBD oil prices tend to be significantly higher at dispensaries.
Among the company’s many offerings is Real Scientific Hemp Oil, which it sells through its subsidiary HempMedsPx, also based in Poway. On its web site, HempMedsPx describes how its hemp “is grown in northern European microclimates, without the use of any pesticides, herbicides or chemical fertilizers.” The company promises that it “continuously scrutinizes and improves the processes to meet all regulations and exceeds quality standards.”
Willie’s Remedy adds to an increasingly crowded field marijuana-based coffee products. There are cold brews in both THC and CBD varieties, coffee pods, dehydrated coffee, and even an American coffee shop where cannabis products can be consumed on premises. But Willie’s Remedy marks the first whole bean offering (to our knowledge), proving yet again that Willie Nelson is truly a pioneer.
Ingredients: Purified Water, Aloe Barbadensis Leaf Extract, Squalane, Glycerin, Stearic Acid, Cetyl Alcohol, Stearyl Alcohol, Ethylene Glycol Distearate, Menthol, Sodium Acrylates Copolymer, Cannabis Sativa Seed Oil, Arnica Montana Flower Extract, Boswellia Serrata Extract, Allantoin, Propylene Glycol, Phenoxyethanol, Ethylhexylglycerin, Lecithin, Glycerylstereate, Peg 100, Stereate, Diasonilidyl, Tocopherol Acetate
Pharmacists have since moved to metric measurements, with a drop being rounded to exactly 0.05 mL (50 μL, that is, 20 drops per milliliter) - https://en.wikipedia.org/wiki/Drop_(unit)1oz is 30 mL1000mg/30mL = 33.3 mg/mL CBD concentration20 drops * .05 mL/drop = 1mL10 drops * .05 mL/drop = .5mLyou take 33.3 mg in the morning and 16.65mg at nightI might suggest taking 50mg in the morning: 50mg / 33.3 mg/mL = 1.50 mL 30 dropstry it for a couple days and see how it helps
The document gives a cursory breakdown of cannabis, cannabinoids like THC and CBD, concentrates and high-CBD/low-THC hemp plants, but only provides recommendations based on results from cases where animals came in to the vet from a toxic reaction. The evidence shows your animal will typically experience effects within 1-3 hours of exposure, but that they can “manifest in as little as 5 minutes or as long as 96 hours.” The AVMA notice also explains that most toxic cases have occurred in young puppies, and that most cases with dogs involved other toxicities such as chocolate, raisins, xylitol or wrapping.
During my visit, Penny showed me how she administers Harper’s CBD oils. We stood in her kitchen, where a window opened onto a vista of green grass and a wooden swing set out back. After carefully mixing and measuring Harper’s oils, Penny poured the liquid into a jumbo-sized plastic syringe. “We put this all online,” she told me, referring to the several YouTube videos she has made to help other parents administer hemp oil. Penny leaned down over her daughter to fit the tip of the syringe into her gastronomy tube, and I stood by silently. Harper looked at Penny, and Penny smiled back at her, and eased the plunger down.
Hi Colleen, it's almost a year later and I'm wondering how you're doing. I'm experiencing a recurrence of Stage 3 ovarian, originally diagnosed in 2011. I've decided to get some chemo, not sold on another 6 cycles though. As a new MMJ patient, I'm still going to go through with Rick Simpson Oil (THC+CBD,) and I just joined a program with my local dispensary to get CBD capsules for $2 each when I order them at least 30 at a time. I hope you're doing well!! I'm off to do more research on dosing. **NOTE: If you have ANY experience with CBD treatment of ovarian cancer, PLEASE respond. Thank you!!
Why should you care about the quality of CBD you buy? Because, the CBD industry is still in its infancy, and it’s easy to get confused, which leads to some brands taking advantage. That’s why we’ve examined the industry, brands and product for you. We’ve hand selected some of the top CBD brands out there; reviewed their history, product quality, price, and customer service for you. Now you can confidently make a more informed decision on which company to trust with your business. Ministry of Hemp may receive a percentage of sales if you purchase a product from one of these links. Read our full disclosure statement.”
Although CBD is a cannabinoid, it does not attach to or directly interact with CB1 or CB2. Instead, CBD indirectly affects/influences signaling through CB1 and CB2, while also increasing levels of bodily produced cannabinoids. CBD does this by inhibiting the activity of a group of enzymes (cytochrome P450 enzymes) that are responsible for breaking down bodily produced cannabinoids (a.k.a. endocannabinoids)

Due to the influence of big pharma,the FDA has refused (until recently) to investigate the benefits of phytocannabinoid oil for humans or pets. We are not allowed to say or imply that phytocannabinoid has any medical benefits, however the 1st Amendment also protects our right to tell you about our experiences with phytocannabinoid helping our own pets, and the fact that there have been more than 1500 clinical studies regarding the effectiveness of phytocannabinoids.The owners and staff of Innovet believe, but cannot legally claim or imply, that countless dogs and cats have used phytocannabinoid oils for many conditions.

No, absolutely not. We source exclusively from 100% organic farms, so this is never an issue. Even though none of our ingredients have ever been exposed to pesticides, we still routinely have our phytocannabinoid oil tested by a third party for potency and the presence of any toxins/pesticides. You can see the results on the certificate of analysis found on our website.


The healing power of salves has been around since man first started using plants for medicinal purposes. Crushing, grinding, and processing powerful herbs helps bring all their natural healing properties straight to your skin, making them far more effective and faster acting than simply eating them. Our 500mg CBDol Salve is a perfect localizing and eliminating your source of discomfort.

THC, tetrahydrocannabinol, the substance responsible for the psychoactive effects for marijuana we associate with getting high, comes with side effects such as reduced short-term memory, impaired thinking and potential anxiety, while CBD, cannabidiol, possesses therapeutic effects such as relief of pain, stress, depression, Alzheimer’s, epilepsy, as well as protecting those parts of the brain associated with memory and learning. CBD's positive effects are due to its ability to bond with receptors in the brain, hence the anti-anxiety, anti-spasmodic and neuroprotective effects, as well as receptors throughout the body, lending itself to anti-inflammation and pain relief. 
Due to the circumstances out of our control, the Black Friday sale will start as soon as our payment processor comes back online. Rest assured that once the payment processor is up and running again, we will be running the best Black Friday sale ever and we will allow plenty of time for orders to be placed! We are working around the clock to resolve this.
“This is a really powerful compound,” says Mikhail Kogan, the medical director of the George Washington University Center for Integrative Medicine. “I’ve seen it work for a lot of my patients.” He prescribes high-CBD strains of cannabis regularly for such illnesses as epilepsy, post-traumatic stress disorder, anxiety, autoimmune disorders, autism and insomnia.

I have crohns dibeates 2 stage kidney failure I take 6000 mg of chemicals a day when I get a flair l might lose a lot of blood I've had fistula surgery once darn mean killed me 2 more just gut surgerys little bit of gut removed I tease my gut doctor he schoold just put in a zipper any way I'm looking for something natural to try for pain also where I live if you get caught automatic life so the delima begins how much would any one suggest starting out with thanks for your time also compared to most of the folks mine seems like a minor problem on this site but I would appreciate some advice I hope all you folks have good lives and remember god always loves you even though sometimes you think he may have forgotten you
Nature’s Script also sells a pet CBD tincture in 150mg, 300mg, and 1,000mg concentrations. As a general rule of thumb, low-concentration oils are a good option for smaller dogs while larger concentrations may be more suitable for larger breeds – but pet owners should always check with their vet beforehand. In addition to standard shipping, Nature’s Script offers expedited delivery for customers in the contiguous U.S.
We don't get many returns, so we don't require any forms or documents; just be sure to include something with your name or order number so that we know which order to refund. We offer a 30-day return period for all our products if they are returned to us unopened and unused. Also, for many of our products, such as PurCBD and PurOtic, we offer a 30-day money back guarantee even if they are opened and completely used.

In his office, however, Hernandez was wary of the CBD boom. He advises well-meaning parents to think twice about voyaging into the world of over-the-counter hemp oil treatments, even if their circumstances are dire. “It’s a huge gimmick that a lot of companies are using,” Hernandez said. “You don’t know what you’re getting. ... There’s a major quality problem.”
It’s hard to believe that with all the benefits of hemp, that it remains illegal in much of the world and in most of America can only be sourced by being imported. But things are changing, in recent decades the push to restart hemp production has been massive and it is changing because of all it’s health benefit discoveries. Some states have legalized cultivation and more plan to. Federally, hemp’s importation is allowed as long as the plant’s THC levels are below 0.3 percent. And that is why we have CBD oil at Winterridge and it’s legal.

Based on reviews, smoking or vaporizing CBD vape oil seems to have less effects when compared to other methods of administering CBD, such as tinctures, capsules and sprays. On the flip side, others argue that smoking or vaporizing has less drawbacks than taking CBD orally, since ingesting CBD orally could result in inconsistent absorption and a delayed effect.


It sounds like the title of a children’s book, but like so much else that you learned in kindergarten, it’s true. Everyone’s body is different – but everyone’s endocannabinoid system is really unique. For reasons we don’t fully understand, receptors in the endocannabinoid system don’t respond predictably to cannabinoids from person to person. This lack of a predictable response makes standard dosing tricky.
The topical menthol ointment is our most common product for direct application to sore joints, muscle tissue, and damaged skin areas. Standard CBD oil drops can take up to an hour (or longer) to take effect (since they have to enter into the bloodstream), but with topical creams, effects are typically felt within minutes as the active cannabidiol simply has to diffuse across the dermal layers and to the site of inflammation.
But it’s not just that coffee shops don’t have to be specific about what CBD in a latte is supposed to do, and thus don’t — legally, they can’t. “Once anyone, outside of the one FDA-approved medication, says ‘Hey, if you drink this, it’ll cure your anxiety, or your seizures, the FDA is going to come knocking at that point,’” says Carson. When shops offer CBD-infused products, then, they are relying on the customer — and perhaps the placebo effect — to fill in the blanks.
The raw and heated cannabinoids in this product come from agricultural hemp. They are combined with hemp terpenes that are steam distilled. We have specially formulated this blend to combine a variety of different terpene-rich hemp extracts. This product contains equal amounts of both CBD (a decarboxylated form of cannabinoid) and CBD-A (the raw, or non-decarboxylated form of cannabinoid) — 125 mg of each, to be exact.
Over decades, researchers have found that THC may help treat pain, nausea, loss of appetite and other problems, while CBD was thought to be biologically inactive in humans. But in the past 10 years, scientists have concluded that CBD may be quite useful. Dozens of studies have found evidence that the compound can treat epilepsy as well as a range of other illnesses, including anxiety, schizophrenia, heart disease and cancer.

To find the store nearest you Click here to use our easy store locator all you have to do is type in your zip code or mailing addresses & the store locator will tell you where the nearest retail location is. We highly recommend calling your local retailer for product availability due to high demand. If the retailer near you does not have the product you are looking for please request the product to the retailer. We are still providing stock to all of our retail locations.


Across all strains, Cannabis sativa L. plants contain 120 identified terpene compounds. These terpenes exist within the resin found on hemp or marijuana flowers. The scent produced by the terpenes helps to determine the quality of each particular cannabis plant strain. It also influences taste, feel, and other senses affected by interaction with the plant or its by-products.
As the demand for CBD products has increased, some states have started to take action. Over the past two years, 17 states have passed “CBD-only” laws, assuring parents who purchase CBD oil to treat their sick children that they won’t face arrest or prosecution from state law enforcement for possessing what the federal government still considers a Schedule I narcotic.

Generally speaking, most marijuana producers and sellers (especially on the black market) don’t test for contaminants (metals, pesticides, bacteria, etc.). Rick Simpson Hemp Oil is actually more a method of extraction than it is a specific product. People use the Rick Simpson method with hundreds of different strains of marijuana, so the THC, CBD and other cannabinoid content of the final oil always vary greatly, depending on the cannabis the consumers are acquiring. Usually what’s used for Rick Simpson oil is a strain with an inferior CBD content (and high THC), because that’s what the vast amount of marijuana is nowadays.
FDA DISCLOSURE Representations regarding the efficacy and safety of Rosebud CBD have not been evaluated by the Food and Drug Administration. The FDA only evaluates foods and drugs, not supplements like these products. These products are not intended to diagnose, prevent, treat, or cure any disease. Click here (https://www.ncbi.nlm.nih.gov/pubmed/22625422) and here (https://www.ncbi.nlm.nih.gov/pubmed/18728714) to find evidence of a test, analysis, research, or study describing the benefits, performance or efficacy of CBD Oil based on the expertise of relevant professionals. These statements have not been evaluated by the FDA and are not intended to diagnose, treat, or cure any disease. Always check with your physician before starting a new dietary supplement program. The Cannabidiol (CBD) in Rosebud CBD is a natural constituent of industrial hemp plant and grown in the United States of America. Rosebud CBD does not sell or distribute any products that are in violation of the United States Controlled Substances Act (US CSA). All products contain less than 0.3% THC. All products are legal in all 50 states.

While researchers are calling for more robust studies on the role of CBD on mood disorders, there is promising research that points to CBD’s role as an anxiolytic – which means it has anti-anxiety effects. Another study showed CBD to have antidepressant effects comparable to those of the prescription antidepressant Imipramine. We noted above that CBD increases levels of glutamate and serotonin – and it’s these same neurotransmitters that play a crucial role in mood regulation.
This may be a good place to point out that not all CBD products are created equal. The industry is still largely unregulated, and the quality and quantity of CBD in a given product will vary wildly. Third party testing definitely helps to monitor companies’ claims, but it’s still up to you as the consumer to do your homework on the best CBD products.
The arrival of Epidiolex is unlikely to erase the unregulated CBD market, however. For one, Epidiolex has been studied only in connection with a small number of epileptic conditions. If and when Epidiolex makes its way to drug stores, it will be approved only for the treatment of Dravet Syndrome and Lennox-Gastaut Syndrome, two rare forms of catastrophic epilepsy. People like me, with comparatively mild Janz Syndrome, and people like Harper, with extremely rare conditions like CDKL5, may still be out of luck.

Among the company’s many offerings is Real Scientific Hemp Oil, which it sells through its subsidiary HempMedsPx, also based in Poway. On its web site, HempMedsPx describes how its hemp “is grown in northern European microclimates, without the use of any pesticides, herbicides or chemical fertilizers.” The company promises that it “continuously scrutinizes and improves the processes to meet all regulations and exceeds quality standards.”


It depends on your pet and the medicine being used. There have been many examples of dogs being more receptive to PurCBD than traditional medications, especially with anti-seizure, anti-inflammatory, and anti-anxiety medications. Always check with your veterinarian before starting, stopping, or adjusting the dosage of any prescription medication. Many drugs, especially anti-seizure medications, must be weaned off slowly or else deadly withdrawal symptoms can occur.
Let's start with the most officially proven medical use of CBD. Earlier this year, the FDA approved the first-ever drug containing CBD, Epidiolex, to treat two rare forms of pediatric epilepsy. To get to that point, the drug's manufacturers had to do a whole lot of randomized, placebo-controlled trials on humans. They had to study how much children could take, what would happen in case of overdose, and any possible side effects that would occur.
×